VivaZome and Cytiva to collaborate on downstream technology for exosome purification

Under the agreement, VivaZome will provide substantial quantities of exosome-rich, cell culture supernatant produced by VivaZome’s preferred cell type. Cytiva’s Next Generation Resins Team, located in Uppsala in Sweden, will use the VivaZome material to evaluate Cytiva chromatography resins and fibre materials for their potential to separate and concentrate exosomes, with an emphasis on demonstrating high purity, very fast flow rates and scale-ability.

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VivaZome and Toolgen extend collaboration based on successful proof-of-concept

Under the pilot study, ToolGen undertook a knock-down gene editing using its CRISPR/Cas9 technology, with the gene and the cell specified by VivaZome. The gene editing was successfully accomplished and exosome production by the edited cells was maintained at high levels.
The nest aim to create a gene-edited cell that could be used in VivaZome’s exosome manufacturing process.

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Sienna and VivaZome to evaluate EXO-NET for VivaZome’s exosome-based therapeutics

Sienna has entered into an agreement with VivaZome to assist in the development of a commercial and scalable purification process for VivaZome’s exosome-based therapies. This will be the first potential therapeutic application of Sienna’s capture technology, EXO-NET. Sienna will provide EXO-NET beads which rapidly and specifically capture exosomes, potentially enabling the development of a commercial purification process for exosomes used in treatment therapies.

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VivaZome appoints David Haylock PhD as CEO

Dr Haylock joined the Company as Chief Scientific Officer (CSO) in July, 2019. In his role as CEO, Dr Haylock will maintain his CSO function. Previously Dr Haylock has held senior leadership and management roles iat CSIRO, the Australian Stem Cell Centre, the Peter MacCallum Cancer Centre and the Institute for Medical and Veterinary Sciences. David has a wealth of experience in stem cell biology, cellular therapies and cell manufacturing, all directly relevant to VivaZome’s exosome therapies.

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VivaZome and ToolGen to collaborate on gene editing for enhanced exosome production

Under the agreement, ToolGen will use its CRISPR/Cas9 technology to introduce gene edits into selected cell types to selectively altering the content and characteristics of exosomes produced by the cells.The agreement includes an option for VivaZome to license ToolGen’s technology, as well as any IP arising from the research program.

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VivaZome awarded $2.18m grant for exosome therapy development

VivaZome Therapeutics has been awarded an Australian Government CRC-P grant of $2.18m in support of the project “Enabling Exosome Therapy: Developing an Advanced Manufacturing Process”, with the funds provided under the Advanced Manufacturing Scheme. Joining VivaZome in the CRC-P are La Trobe University and SeerPharma Pty Ltd, each of which bring high-level scientific and operational skills to the 3 –year project. VivaZome will also engage with the CSIRO to provide expertise in industrial–scale manufacturing.

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