BIA’s unique CIM (Convective Interaction Media) monolith chromatography technology will be used to purify exosomes from VivaZome’s cell cultures, with the aim of developing a high-efficiency downstream purification and concentration process for exosome production.
Click to read full media release. http://vivazome.com/wp-content/uploads/2021/01/VivaZome-BIA-release-21-Dec-2020.pdf
VivaZome features in lead article in International BioPharmaceutical Industry journal. “Exosome Therapeutics: Academic Curiosity or Commercial Reality” written by VivaZome CEO David Haylock and key academic collaborator Prof Andy Hill (La Trobe Uni).
Click here to read article: 2020-IBI_Summer-Vivazome
VivaZome’s David Haylock says his company’s decision to base themselves in the Research & Innovation Precinct at La Trobe University revolved largely around one key researcher. Read the full story here
VivaZome features in “Inspire” – Research Australia’s Showcase for Health and Medical Research and Innovation. Download the article here:
Under the agreement, VivaZome will provide substantial quantities of exosome-rich, cell culture supernatant produced by VivaZome’s preferred cell type. Cytiva’s Next Generation Resins Team, located in Uppsala in Sweden, will use the VivaZome material to evaluate Cytiva chromatography resins and fibre materials for their potential to separate and concentrate exosomes, with an emphasis on demonstrating high purity, very fast flow rates and scale-ability.
Under the Licence Agreement, VivaZome has secured world-wide rights to intellectual property for the selection, isolation, purification, expansion and processing of stem cells from certain human tissues suitable for production of subcellular fractions. VivaZome will process these fractions to generate exosome products.
Under the pilot study, ToolGen undertook a knock-down gene editing using its CRISPR/Cas9 technology, with the gene and the cell specified by VivaZome. The gene editing was successfully accomplished and exosome production by the edited cells was maintained at high levels.
The nest aim to create a gene-edited cell that could be used in VivaZome’s exosome manufacturing process.
Sienna has entered into an agreement with VivaZome to assist in the development of a commercial and scalable purification process for VivaZome’s exosome-based therapies. This will be the first potential therapeutic application of Sienna’s capture technology, EXO-NET. Sienna will provide EXO-NET beads which rapidly and specifically capture exosomes, potentially enabling the development of a commercial purification process for exosomes used in treatment therapies.
Dr Haylock joined the Company as Chief Scientific Officer (CSO) in July, 2019. In his role as CEO, Dr Haylock will maintain his CSO function. Previously Dr Haylock has held senior leadership and management roles iat CSIRO, the Australian Stem Cell Centre, the Peter MacCallum Cancer Centre and the Institute for Medical and Veterinary Sciences. David has a wealth of experience in stem cell biology, cellular therapies and cell manufacturing, all directly relevant to VivaZome’s exosome therapies.
Under the agreement, ToolGen will use its CRISPR/Cas9 technology to introduce gene edits into selected cell types to selectively altering the content and characteristics of exosomes produced by the cells.The agreement includes an option for VivaZome to license ToolGen’s technology, as well as any IP arising from the research program.